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1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature;
615(7953): 678-686, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36922586
2.
Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Clin Infect Dis;
77(6): 857-865, 2023 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37161721
3.
Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy.
Am J Respir Crit Care Med;
205(5): 570-579, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34939891
4.
Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor.
Toxicol Pathol;
49(6): 1193-1205, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34128434
5.
Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection.
Antimicrob Agents Chemother;
63(4)2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30745396
6.
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorg Med Chem Lett;
22(9): 3265-8, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22472694
7.
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother;
55(8): 3812-20, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21576430
8.
Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.
Drug Metab Dispos;
37(4): 809-20, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19131522
9.
Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.
PLoS Negl Trop Dis;
13(1): e0007026, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30650076
10.
Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.
PLoS Negl Trop Dis;
13(1): e0006787, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30650084
11.
Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery.
Adv Healthc Mater;
8(9): e1801510, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30838804
12.
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
PLoS Negl Trop Dis;
13(1): e0006320, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30650105
13.
Hemorrhagic cardiomyopathy in male mice treated with an NNRTI: the role of vitamin K.
Toxicol Pathol;
36(2): 321-9, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18367644
14.
Dog model with implanted pump to test boosters for antiretroviral medication.
Int J Pharm;
355(1-2): 45-52, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18082980
15.
Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension.
J Control Release;
292: 119-129, 2018 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30395897
16.
Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.
J Med Chem;
59(12): 5790-8, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27181575
17.
Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole.
J Pharm Sci;
105(9): 2782-2793, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27113473
18.
Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.
J Med Chem;
57(5): 1836-44, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24345201
19.
2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem;
53(22): 8150-60, 2010 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21033671
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